Refolding agent and refolding method of protein

摘要

The present invention provides a refolding agent which is preferably used in terms of the conformation of the native activity with reconstruction to (refolding), and protein unfolded. I also provide reproduction method of the protein using the refolding agent (refolding method). As refolding agents for proteins that are unfolded, amide derivatives and ester derivatives and amide derivatives derivatives of oxidized glutathione, reduced glutathione, and according the present invention, from the group consisting of solvates and acid addition salts thereof It is characterized by the use of as an active ingredient at least one that is selected.