To provide a protein refolding agent capable of efficiently refolding protein.SOLUTION: A protein refolding agent comprises as an active ingredient at least one selected from the group consisting of compounds represented by the formula (I) in the figure, and salts and solvates thereof. In the formula, X is a substituted or unsubstituted, linear or branched, divalent hydrocarbon group where the number of carbon atoms is from 1 to 10 inclusive, or a substituted or unsubstituted polyoxyalkylene group where the number of repeats is from 1 to 10 inclusive.SELECTED DRAWING: Figure 5
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