COMPOSITION FOR HARD TISSUE FORMATION AND, DENTIN OR PULP REGENERATION CONTAINING AMELOBLAST, APICAL BUD CELL OR ITS CULTURE FLUID AS AN ACTIVE INGREDIENT

摘要

The present invention relates to a composition for hard tissue formation and dentin, or dental pulp regeneration comprising ameloblasts, apical bud cells, or its culture fluid as an active ingredient. The ameloblasts, apical bud cells, or its culture fluid promotes the differentiation of odontoblasts, human dental pulp stem cells and osteoblasts, increases DSPP promoter activity, induces dental pulp regeneration of dental pulp stem cells, and induces hard tissue formation significantly in vivo, so that they can be effectively used for a composition for promoting hard tissue formation and dentin or dental pulp regeneration.