首页> 外国专利> AUXOTROPHIC RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF IN THE CONTROL OF HUMAN INFECTIONS CAUSED BY PARASITES

AUXOTROPHIC RECOMBINANT BCG STRAIN PASTEUR AND USE THEREOF IN THE CONTROL OF HUMAN INFECTIONS CAUSED BY PARASITES

机译：营养缺陷型重组BCG菌株糊剂及其在控制寄生虫引起的人类感染中的应用

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摘要

The present invention relates to a vaccinal strain of recombinant BCG Mycobacterium bovis expressing the Schistossoma mansoni Sm14 protein (BCG Pasteur ΔleuD/pΔK410-hsp60*-Sm14). The vaccinal strain of the present invention is employed in the control of infections caused by parasites, specially the Schistossoma mansoni. The vaccinal strain is a an auxotrophic strain to leucine amino acid derived from the BCG Pasteur sub-strain complemented to leucine after genetic transformation with the construct pΔK410-hsp60*-Sm14. The efficacy of the BCG Pasteur ΔleuD/pΔK410-hsp60*-Sm14 strain in the control of the Schistossoma mansoni infection based on the recombinant Sm14 antigen in vivo is showed in the present invention.

机译：本发明涉及一种表达曼氏血吸虫 Sm14蛋白（BCG PasteurΔleuD/pΔK410-hsp60* -Sm14）的重组BCG 牛分枝杆菌的疫苗株。本发明的疫苗株用于控制由寄生虫特别是曼氏血吸虫引起的感染。疫苗菌株是对BCG巴斯德亚菌株衍生的亮氨酸氨基酸的营养缺陷型菌株，在用构建体pΔK410-hsp60* -Sm14进行遗传转化后与亮氨酸互补。本发明显示了BCG PasteurΔleuD/pΔK410-hsp60* -Sm14菌株在体内基于重组Sm14抗原控制曼氏血吸虫感染的功效。 展开▼

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公开/公告号US2012093774A1

专利类型

公开/公告日2012-04-19

原文格式PDF

申请/专利权人 MIRIAM TENDLER;MONICA MAGNO VILAR;GERALDO RODRIGUES GARCIA ARMOA;DOUGLAS MCINTOSH;ANDREW J.G. SIMPSON;
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申请/专利号US201013255734

发明设计人 MIRIAM TENDLER;MONICA MAGNO VILAR;GERALDO RODRIGUES GARCIA ARMOA;DOUGLAS MCINTOSH;ANDREW J.G. SIMPSON;
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申请日2010-03-10

分类号A61K48;A61P33;C12Q1/02;

国家 US

入库时间 2022-08-21 17:33:41

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