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Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti

机译：鉴定与毒力相关的区域RD1和RD5，从而改善牛分枝杆菌BCG和微量分枝杆菌的疫苗

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摘要

The present invention relates to a strain of M. bovis BCG or M. microti, wherein said strain has integrated part or all of the RD1 region responsible for enhanced immunogenicity of the tubercle bacilli, especially the ESAT-6 and CFP-10 genes. These strains will be referred as the M. bovis BCG::RD1 or M. microti::RD1 strains and are useful as a new improved vaccine for preventing tuberculosis and as a therapeutical product enhancing the stimulation of the immune system for the treatment of bladder cancer.

机译：本发明涉及M株。牛 BCG或 M。菌，其中所述菌株具有负责增强结核杆菌，特别是ESAT-6和CFP-10基因免疫原性的RD1区的部分或全部。这些菌株将被称为。 bovis BCG :: RD1或 M。 microti :: RD1菌株，可用作预防结核病的新型改良疫苗和增强刺激免疫系统的治疗性产品，以治疗膀胱癌。 展开▼

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公开/公告号US2012189662A1

专利类型

公开/公告日2012-07-26

原文格式PDF

申请/专利权人 STEWART COLE;ALEXANDER S. PYM;ROLAND BROSCH;PRISCILLE BRODIN;LALEH MAJLESSI;CAROLINE DEMANGEL;CLAUDE LECLERC;
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申请/专利号US20100923432

发明设计人 STEWART COLE;ALEXANDER S. PYM;ROLAND BROSCH;PRISCILLE BRODIN;LALEH MAJLESSI;CAROLINE DEMANGEL;CLAUDE LECLERC;
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申请日2010-09-21

分类号A61K39/04;C12N15/74;A61K35/74;A61P37/04;A61P35;C12Q1/68;C12P21;C07H21/04;C12N1/21;A61P31/06;

国家 US

入库时间 2022-08-21 17:33:35

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3. IDENTIFICATION OF VIRULENCE ASSOCIATED REGIONS RD1 AND RD5 LEADING TO IMPROVE VACCINE OF M. BOVIS BCG AND M. MICROTI [P] . CA2481318C . 2014-06-10

机译：鉴定有助于提高牛分枝杆菌BCG和微分枝杆菌疫苗接种率的毒力相关区域RD1和RD5

4. Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti [P] . 美国专利： US8747866B2 . 2014-06-10

机译：鉴定与毒力相关的区域RD1和RD5，从而改善ImM疫苗。 bovis BCG和 M。微量滴

5. Identification of virulence associated regions RD1 and RD5 leading to improve vaccine of M. bovis BCG and M. microti [P] . 美国专利： US7883712B2 . 2011-02-08

机译：鉴定与毒力相关的区域RD1和RD5，从而改善ImM疫苗。 bovis BCG和 M。小提琴

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4. Influence of Anti-tuberculosis Drug KIM-M2 on Morphology of Lymph Nodes, Spleen, Liver and Lungs of Guinea Pigs Infected with M. bovis [C] . Vasiliy Vlasenko, Valentina Pleshakova, Yuriy Gichev International Scientific and Practical Conference on Digitization of Agriculture - Development Strategy . 2019

5. Identification of L1334, a unique glycopeptidolipid isolated from a M. smegmatis MSMEG1604 mutant and functional characterization of Rv3409c from M. tuberculosis. [D] . Gao, Jin. 2010

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7. Diagnostic and Vaccine Potentials of ESAT-6 Family Proteins encoded by M. tuberculosis genomic regions absent in M. bovis BCG [O] . Abu Salim Mustafa 2013

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