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Enhanced Binding of Pro-Inflammatory Cytokines by Polysaccharide-Antibody Conjugates
Enhanced Binding of Pro-Inflammatory Cytokines by Polysaccharide-Antibody Conjugates
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机译:多糖抗体结合物增强促炎细胞因子的结合。
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摘要
We provide monoclonal antibodies against interleukin-1β and tumor necrosis factor-α that remain biologically active in vitro when conjugated to high molecular weight polysaccharides. We report enhanced binding of these cytokines when their monoclonal antibodies are conjugated to alginate compared to non-conjugated monoclonal antibodies. In cell assays, polysaccharide-antibody constructs of the invention inhibited cytokine signaling to comparable levels as that of unmodified antibodies. Conjugation of cytokine-neutralizing antibodies to high molecular weight polymers enhances the affinities cytokine-binding moieties used as anti-inflammatory therapeutics.
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