首页> 外国专利> Composition Comprising the Extract of Anemarrhena Asphodeloides Bunge or the Compounds Isolated from the Same for Preventing and Treating Lipid Metabolism Disorder

Composition Comprising the Extract of Anemarrhena Asphodeloides Bunge or the Compounds Isolated from the Same for Preventing and Treating Lipid Metabolism Disorder

机译：用于预防和治疗脂质代谢紊乱的知母二倍体提取物或从其中提取的化合物的组合物

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摘要

The present invention relates to a composition comprising an extract of Anemarrhena asphodeloides Bunge or the compounds isolated from the same, as an active ingredient. In particular, the extract and compounds have the excellent inhibitory effects on adipocyte differentiation, and thus can be used in a pharmaceutical composition and functional food for the prevention and treatment of lipid metabolism disorders.

机译：本发明涉及一种组合物，其包含知母草提取物或从中提取的化合物作为活性成分。特别地，所述提取物和化合物对脂肪细胞分化具有优异的抑制作用，因此可以用于药物组合物和功能性食品中以预防和治疗脂质代谢紊乱。

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公开/公告号US2012070515A1

专利类型
公开/公告日2012-03-22

原文格式PDF
申请/专利权人 EUN KYOUNG SEO;EUN SOOK HWANG;UI JOUNG YOUN;JOO WON NAM;
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申请/专利号US200913264451
发明设计人 EUN KYOUNG SEO;EUN SOOK HWANG;UI JOUNG YOUN;JOO WON NAM;
展开▼

申请日2009-12-08
分类号A61K36/88;C07C49/796;A61P9/10;A61P3;A61P3/04;A61P3/10;C07D311/22;A61P3/06;
国家 US
入库时间 2022-08-21 17:32:20

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2. Association between polymorphism of MC4R rs489693 gene and disorder of glucose and lipid metabolism in schizophrenia patients treated with olanzapine [J] . Tian-Dao Wang, Ming Pan, Xiang-Lai Liu, 海南医科大学学报(英文版) . 2020,第017期

3. Association between polymorphism of MC4R rs489693 gene and disorder of glucose and lipid metabolism in schizophrenia patients treated with olanzapine [J] . Tian-Dao Wang, Ming Pan, Xiang-Lai Liu, 海南医科大学学报（英文版） . 2020,第017期

4. 7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors. [J] . Tsukamoto S, Wakana T, Koimaru K, Biological & pharmaceutical bulletin . 2005,第9期

5. Antimicrobial, Antioxidant and Cellular Protective Effects against Oxidative Stress of Anemarrhena asphodeloides Bunge Extract and Fraction [J] . Yun Ju Lee, Ba Reum Song, Sang Lae Lee, Microbiology and biotechnology letters . 2018,第4期

6. COMPOSITION COMPRISING AN EXTRACT OF HARDY KIWI FOR PREVENTING OR TREATING BALDNESS DISORDERS OR SEBORRHEIC SKIN DISORDERS [J] . Soap Perfumery and Cosmetics group Soap, Perfumery and Cosmetics . 2014,第12期

7. Antifungi efficacy of the compound preparation of anemarrhena asphodeloides bunge on the drug resistant strain of Candida albicans [C] . Lianlan Ma, Zhichun Liu, Wenping Zhang, ICEEP 2012 . 2012

8. Effects of dietary lipids on growth, fatty acid composition, and lipid metabolism of the green sea urchin Strongylocentrotus droebachiensis. [D] . Gonzalez-Duran, Enrique Alfonso. 2003

9. Pharmacological Activity Pharmacokinetics and Toxicity of Timosaponin AIII a Natural Product Isolated From Anemarrhena asphodeloides Bunge: A Review [O] . Yan Lin, Wai-Rong Zhao, Wen-Ting Shi, 2020

10. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). 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V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

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