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BACTERIAL CELLS, OPTIMIZED NUCLEOTIDE SEQUENCES AND METHODS FOR IMPROVED EXPRESSION OF RECOMBINANT CLOSTRIDIUM DIFFICILE TOXIN B
BACTERIAL CELLS, OPTIMIZED NUCLEOTIDE SEQUENCES AND METHODS FOR IMPROVED EXPRESSION OF RECOMBINANT CLOSTRIDIUM DIFFICILE TOXIN B
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机译:细菌细胞,优化的核苷酸序列和重组重组艰难梭菌毒素B的表达方法
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摘要
In some embodiments, the present invention provides isolated nucleotide sequences that encode Clostridium difficile toxin B, wherein the isolated nucleotide sequences have been optimized for improved expression of the toxin B in a bacterial cell. Other embodiments of the present invention pertain to methods of expressing recombinant Clostridium difficile toxin B in a bacterial cell from the isolated nucleotide sequences of the present invention. In other embodiments, the present invention pertains to bacterial cells that comprise the isolated nucleotide sequences of the present invention. In further embodiments, the invention pertains to isolated peptides of recombinant Clostridium difficile toxin B that were derived from the isolated nucleotide sequences of the present invention.
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