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Genome editing of a Rosa locus using zinc-finger nucleases

机译：使用锌指核酸酶对罗莎基因座进行基因组编辑

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摘要

Disclosed herein are methods and compositions for genome editing of a Rosa locus, using fusion proteins comprising a zinc-finger protein and a cleavage domain or cleavage half-domain. Polynucleotides encoding said fusion proteins are also provided, as are cells comprising said polynucleotides and fusion proteins.

机译：本文公开了使用包含锌指蛋白和切割结构域或切割半结构域的融合蛋白对Rosa位点进行基因组编辑的方法和组合物。还提供了编码所述融合蛋白的多核苷酸，以及包含所述多核苷酸和融合蛋白的细胞。

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公开/公告号US2012017290A1

专利类型
公开/公告日2012-01-19

原文格式PDF
申请/专利权人 XIAOXIA CUI;GREGORY DAVIS;PHILIP D. GREGORY;MICHAEL C. HOLMES;EDWARD J. WEINSTEIN;
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申请/专利号US201113066802
发明设计人 XIAOXIA CUI;GREGORY DAVIS;PHILIP D. GREGORY;MICHAEL C. HOLMES;EDWARD J. WEINSTEIN;
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申请日2011-04-25
分类号A01K67/033;C12N15/62;C12N15/01;A61K38/46;A61K31/7088;C12N9/96;C12N5/10;
国家 US
入库时间 2022-08-21 17:31:03

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