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Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate
Asymmetric Cobalt-Catalyzed Cyclopropanation With Succinimidyl Diazoacetate
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机译:琥珀酰亚胺重氮乙酸酯的不对称钴催化环丙烷化
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摘要
Cobalt(II) complexes of the D2-symmetric chiral porphyrins are effective catalysts for asymmetric cyclopropanation reactions with succinimidyl diazoacetate. The Co-catalyzed reaction is suitable for various olefins, providing the corresponding cyclopropane succinimidyl esters in high yields and excellent diastereo- and enantio-selectivity. The resulting enantioenriched cyclopropane succinimidyl esters can serve as convenient synthons for the general synthesis of optically active cyclopropyl carboxamides through mild reactions with a wide range of amine derivatives, including unprotected peptides and amino sugars
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