MICROFLUIDIC DEVICE FOR DETECTION OF MITOCHONDRIAL DNA VIA ELECTROCHEMILUMINESCENCE MODULATED HYBRIDIZATION

摘要

A microfluidic device for analysis of mitochondrial DNA in a sample, the microfluidic device having an inlet for receiving a sample of biological material having cells with mitochondria containing mitochondrial DNA, a lysis section for lysing the mitochondria to release the mitochondrial DNA, electrochemiluminescent (ECL) resonance energy transfer probes for hybridization with target nucleic acid sequences in the mitochondrial DNA to form probe-target hybrids, and, a photosensor for detecting the probe-target hybrids.