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Use of flagellin in the immunotherapy of Yersinia pestis

机译：鞭毛蛋白在鼠疫耶尔森氏菌的免疫治疗中的应用

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摘要

The invention provides a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. Also provided are compositions comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention also discloses methods of making a fusion protein comprising a flagellin adjuvant and a Yersinia pestis antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against Yersinia pestis. 展开▼

机译：本发明提供了包含鞭毛蛋白佐剂和鼠疫耶尔森氏菌抗原的融合蛋白。还提供了包含鞭毛蛋白佐剂和鼠疫耶尔森氏菌抗原的组合物。本发明还公开了制备包含鞭毛蛋白佐剂和鼠疫耶尔森氏菌抗原的融合蛋白的方法。本发明进一步提供了用于诱导针对鼠疫耶尔森氏菌的免疫应答的药物制剂和方法。展开▼

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公开/公告号US8198424B2

专利类型

公开/公告日2012-06-12

原文格式PDF

申请/专利权人 STEVEN B. MIZEL;ANNA NICHOLE HONKO;
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申请/专利号US20100837223

发明设计人 STEVEN B. MIZEL;ANNA NICHOLE HONKO;
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申请日2010-07-15

分类号C07H21/04;C12N15;C12N15/09;C12P21/04;

国家 US

入库时间 2022-08-21 17:30:30

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1. 鞭毛蛋白在鼠疫耶尔森氏菌的免疫疗法中的用途 [P] . 中国专利： CN101094685B . 2016.01.13

2. 鞭毛蛋白在鼠疫耶尔森氏菌的免疫疗法中的用途 [P] . 中国专利： CN101094685A . 2007-12-26

3. USE OF FLAGELLIN IN THE IMMUNOTHERAPY OF YERSINIA PESTIS [P] . CA2589553C . 2014-02-18

机译：氟西林在耶尔森氏菌免疫治疗中的应用

4. Use of flagellin in immunotherapy of Yersinia pestis [P] . 日本专利： JP5094407B2 . 2012-12-12

机译：鞭毛蛋白在鼠疫耶尔森氏菌免疫治疗中的应用

5. USE OF FLAGELLIN IN THE IMMUNOTHERAPY OF YERSINIA PESTIS [P] . 欧洲知识产权局专利： EP1824510B1 . 2012-10-31

机译：氟西林在耶尔森氏菌免疫治疗中的应用

1. Reciprocal Regulation between Fur and Two RyhB Homologs in Yersinia pestis, and Roles of RyhBs in Biofilm Formation [J] . NI Bin, WU Hai Sheng, XIN You Quan, 生物医学与环境科学（英文版） . 2021,第004期

2. Rapid Detection of Yersinia pestis by Real-time Recombinase- aided Amplification [J] . WEI Xiao, LI Yan, LU Xin, 生物医学与环境科学（英文版） . 2021,第004期

3. Optimized Methods for Biofilm Analysis in Yersinia pestis [J] . FANG Nan, GAO He, WANG Li, 生物医学与环境科学（英文版） . 2013,第005期

4. Comparative Genomic Analysis of Gene Variations of Two Chinese Yersinia pestis Isolates from Vaccine Strain EV76 [J] . YOU Yuan Hai, ZHANG Jian Zhong, WANG Peng, 生物医学与环境科学（英文版） . 2012,第004期

5. Use of Rich BHI Medium Instead of Synthetic TMH Medium for Gene Regulation Study in Yersinia pestis [J] . ZHANG Yi Quan, MA Li Zhi, WANG Li, 生物医学与环境科学（英文版） . 2012,第006期

6. Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge with Yersinia pestis [J] . Anna N. Honko, Nammalwar Sriranganathan, Cynthia J. Lees, Infection and immunity . 2006,第2期

7. Differentiation of Yersinia pseudotuberculosis, Yersinia pestis subsp pestis and subsp microti strains and other representatives of Yersinia pseudotuberculosis complex [J] . Kislichkina A. A., Kadnikova L. A., Platonov M. E., Molecular Genetics , Microbiology and Virology: Molekulyarnaya Genetika , Mikrobiologiya i Virusologiya . 2017,第2期

8. The 102-Kilobase pgm Locus of Yersinia pestis: Sequence Analysis and Comparison of Selected Regions among Different Yersinia pestis and Yersinia pseudotuberculosis Strains [J] . Carmen Buchrieser, Christophe Rusniok, Lionel Frangeul, Infection and immunity . 1999,第9期

9. Yersinia pestis and Yersinia pseudotuberculosis diversity in the former Soviet Union and Mongolia [C] . Andrey P. Anisimov International symposium on bacterial genomics, evolution and pathogenesis. . 2010

10. Flagellin is an effective mucosal adjuvant for immunization against lethal respiratory challenge with Yersinia pestis. [D] . Honko, Anna N. 2005

11. Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge with Yersinia pestis [O] . Anna N. Honko, Nammalwar Sriranganathan, Cynthia J. Lees, 2006

12. Flagellin Is an Effective Adjuvant for Immunization against Lethal Respiratory Challenge with Yersinia pestis [O] . Honko, Anna N., Sriranganathan, Nammalwar, Lees, Cynthia J., 2006

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