Synthesis of 1-¹³Cpyruvic acid, 2-¹³Cpyruvic acid, 3-¹³Cpyruvic acid and combinations thereof

摘要

The present invention is directed to the labeled compounds,; wherein C* is each either ¹³C and ¹²C where at least one C* is ¹³C, each hydrogen of the methylene group is hydrogen or deuterium, the methyl group includes either zero or three deuterium atoms, Q is sulfide, sulfinyl, or sulfone, Z is an aryl group such as 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, or a phenyl group; wherein R₁, R₂, R₃, R₄ and R₅ are each independently either hydrogen, a C₁-C₄ lower alkyl, a halogen, and an amino group such as NH₂, NHR and NRR′ where R and R′ are each independently either a C₁-C₄ lower alkyl, a phenyl, and an alkoxy group, and the methyl group can include either zero or three deuterium atoms.;The present invention is also directed to the labeled compounds;