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Pharmaceutical compositions and methods for preventing, treating, or reversing neuronal dysfunction

机译:预防,治疗或逆转神经元功能障碍的药物组合物和方法

摘要

The present invention provides compositions and methods for preventing, treating or reversing neuronal dysfunction in a mammal resulting from exposure to organophosphate nerve agents, organophosphate insecticides and incapacitating agents of the central nervous system (CNS); CNS injury, including traumatic brain injury, neurologic complications of cardiac surgery, perinatal asphyxia, and stroke, spinal cord injury, and peripheral nerve injury; and neuronal disorders associated with the loss of motor function including post-polio syndrome, amyotrophic lateral sclerosis, myasthenia gravis, Parkinson's disease and Rett syndrome; neurodegenerative disorders including Alzheimer's disease, mild cognitive impairment and schizophrenia; and cognitive impairment associated with aging. The compositions of the invention preferably comprise in effective amounts (a) at least one acetylcholinesterase inhibitor, (b) at least one compound with anticholinergic properties or both anticholinergic and antiglutamatergic properties, (c) optionally an anticonvulsive compound, and a pharmaceutically acceptable carrier.
机译:本发明提供了用于预防,治疗或逆转哺乳动物由于暴露于中枢神经系统(CNS)的有机磷酸酯神经药,有机磷酸酯杀虫剂和致残剂而引起的神经元功能障碍的组合物和方法;中枢神经系统损伤,包括颅脑损伤,心脏外科手术的神经系统并发症,围产期窒息和中风,脊髓损伤和周围神经损伤;与运动功能丧失有关的神经元疾病,包括:脊髓灰质炎后综合征,肌萎缩性侧索硬化,重症肌无力,帕金森氏病和瑞特综合征;神经退行性疾病,包括阿尔茨海默氏病,轻度认知障碍和精神分裂症;和与衰老相关的认知障碍。本发明的组合物优选以有效量包含(a)至少一种乙酰胆碱酯酶抑制剂,(b)至少一种具有抗胆碱能特性或抗胆碱能和抗谷氨酸能特性的化合物,(c)任选的抗惊厥化合物和药学上可接受的载体。

著录项

  • 公开/公告号US8299062B2

    专利类型

  • 公开/公告日2012-10-30

    原文格式PDF

  • 申请/专利权人 FRANKLIN VOLVOVITZ;

    申请/专利号US20040943502

  • 发明设计人 FRANKLIN VOLVOVITZ;

    申请日2004-09-17

  • 分类号A61K31/27;A61K31/435;A61K31/47;A61K31/55;A61K31/4353;A61K31/4748;A61K31/445;A61K31/5513;A61K31/551;A61K31/216;

  • 国家 US

  • 入库时间 2022-08-21 17:29:39

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