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Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
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机译:包含VEGF FLT-1和KDR结构域的可溶性嵌合蛋白抑制新血管形成
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摘要
Described herein are novel soluble chimeric fusion proteins comprising amino acid sequences derived from the vascular endothelial growth factor (VEGF) receptors flt-1 and KDR, including domain 4 of KDR. The claimed chimeric fusion proteins antagonize the endothelial cell proliferative and angiogenic activity of VEGF and are useful in the treatment of neovascularization-related disease.
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