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Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery system
Arginine-conjugated bioreducible poly(disulfide amine) polymers for gene delivery system
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机译:精氨酸偶联的生物可还原聚二硫胺聚合物,用于基因递送系统
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摘要
An arginine-grafted bioreducible poly(disulfide amine) (“ABP”) as a reagent for efficient and nontoxic gene delivery is described. ABP forms positively charged nano-particles of less than 200 nm with siRNA. ABP is biodegraded under reducing conditions, such as in the cytoplasm. ABP exhibits much higher transfection efficiency than polyethyleneimine in mammalian cells and exhibits no cytotoxicity. ABP is an effective delivery vehicle for gene silencing with siRNA and may be used for treating cancer.
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