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Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
Nucleic acids encoding genetically modified tissue factor pathway inhibitor (TFPI) and method of making the same
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机译:编码基因修饰组织因子途径抑制剂(TFPI)的核酸及其制备方法
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摘要
The present invention provides long half life genetically modified TFPI sequences (LTFPI) for anticoagulation. On the genetically modified TFPI sequence, the lysine at the carboxy-terminal sites 241, 254, 260 and 261 are replaced by alanin and the amino acid asparagine at glycosylation sites 117, 167, 228 and the amino acids serine and threonine at glycosylation sites 174 and 175 are substitutionally mutated. The present invention also provides methods of making the LTFPI through high efficient LTFPI expression from yeast production system.
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