首页> 外国专利> Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent

Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent

机译:具有脲基,氨基碳原子基团和可以具有取代基的双环基团作为取代基的吡咯衍生物

摘要

A compound represented by the following formula (1) or a salt thereof:; embedded image The compound has an inhibitory activity on the production of interleukin-6, and is therefore useful as a therapeutic agent for a disease associated with interleukin-6, ocular inflammatory diseases and the like. In the formula, R1 represents a halogen atom, a hydrogen atom, a lower alkyl group which may have a substituent, a formyl group, or a lower alkylcarbonyl group which may have a substituent, R2 represents a bicyclic hydrocarbon group which may have a substituent or a bicyclic heterocyclic group which may have a substituent, R3 represents a hydrogen atom, a lower alkyl group which may have a substituent, an aryl group which may have a substituent, or an acyl group.
机译:下式(1)表示的化合物或其盐: “嵌入式图像” 该化合物对白介素-6的产生具有抑制活性,因此可用作与白介素-6有关的疾病,眼炎性疾病等的治疗剂。式中,R 1 表示卤素原子,氢原子,可以具有取代基的低级烷基,甲酰基或可以具有取代基的低级烷基羰基。 > 2 表示可能具有取代基的双环烃基或可能具有取代基的双环杂环基,R 3 表示氢原子,可能具有取代基的低级烷基,可以具有取代基的芳基或酰基。

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