Antagonist Antibody and its Fab Fragments against the Protein of Human platelet Membrane glycoprotein VI (GPVI) and their uses

摘要

This describes Antibodies that Bind specifically to the Protein of Human platelet Membrane glycoprotein VI (GPVI) and monovalent Fragments or Derivatives. The Antibodies of the present are 390 hybridoma Clone Antibody and Antibody fragment capable of inducing a phenotype of reduced GPVI.These Antibodies and fab Fragments can block the binding of collagen and thus prevent platelet Activation by Collagen. Also refers to hybridoma clones and expression Plasmid for the production of Antibodies and fab Fragments described.Also refers to the use of monovalent Antibody fragments to produce Agents Research, Diagnostic and immunotherapeutic Treatment of Thrombosis for other vascular pathologies. Also refers to Fab that supports a Molecule at the c-terminal End, so as to avoid the recognition Method by using the modified Fab Fab Antibodies.This refers to a method for Preventing platelet Activation when using an anti GPVI Fab.