Therapeutic Proteins Binding to a ligand of the vasculature Delta Notch receptor 4 (Dll4), Nucleic Acids encoding the binding protein, Vectors and host Cells

摘要

Dll4 binding proteins, including Antibodies, Antibody with CDR grafting, Humanized Antibodies and Fragments of Dll4 Binding to these Proteins which bind to Dll4 Protein with High affinity and binding activity of Dll4 neutralizing Dll4 and / or Growth Factor (veff) Or vascular endothelial.Dll4 binding proteins are used to Treat or prevent various types of Cancer and tumors and, in particular, to Treat or prevent angiogenesis of tumors.