(R) - N - (3 - (1H - indazol - 7 - methyl - 5 - il) 1 - (4 - (1 - metilpiperidin - 4-yl) piperazin-1-yl) - 1 - oxopropan - 2 - il) - 4 - (2 - oxo - 1.2 - dihidroquinolin - 3 Piperidine - il) - 1 Receptor Antagonist CGRP - carboxamide.

摘要

Compound of Formula 1, (R) - N - (3 - (1H - indazol - 7 - methyl - 5 - (ii) - 1 - (4 - (1 - metilpiperidin piperazin - 4-yl) - 1 - (ii) - 1 - oxopropan - 2 - (ii) - 4 - (2 - oxo - 1.2 - dihidroquinolin II) piperidin - 3 - 1 - carboxamide, including pharmaceutically acceptable salts, which is a receptor antagonist of CGRP.Also compositions and pharmaceutical use of the compound in the treatment of disorders associated with CGRP, including migrana, Neurogenic Neurogenic vasodilation, inflammation, damage of heat shock associated with Menopause, hot flashes, respiratory diseases inflamato Rias, such as Asthma, chronic obstructive pulmonary disease (COPD) and cancer.