Oily Dispersions of neonicotinoids linked to nAChR

摘要

Neocotinoides Insect Selective active ingredients are a class of insecticides that share some characteristics in their Chemical structures and bind to receptors acetilcolinos nAChR.The formulation of the above compounds in oily Oily suspension or dispersion is challenging due to their Electrostatic Interactions with heteroatoms in oily media, leading to irreversible Flocculation or homogeneity and reduced drainage of the above-mentioned dispersion Oily ones.Tiacloprida, imidacloprid, Thiamethoxam, clothianidin and acetamiprida, penconazole, dinetofurano and Derivatives thereof with capacity to bind the nAChR were successfully in oily suspension with the use of certain copolimu00e9ricos Anionic dispersants based on Fatty Acid derivatives Sorbitan, Ionic Surfactants, non-ionic Surfactants,Multifunctional inorganic Salt cationic dispersed in oil. The formulations produced this way Exhibit Properties of excellent storage stability with respect to physico-chemical parameters, including the stability of the active ingredient neonicotinoid, reduced drainage and dispersibility.Also Exhibit excellent Biological Effectiveness due to the small particle size and homogeneous under 2 mm - Emulsify - When diluted in water. Claim 1: Oily dispersion, characterized in that it contains, with respect to the total weight of the formulation of the Oily dispersion: a) at least one neonicotinoid, or mixtures thereof, with a Weight of 0.5 - 40%, (b) a mixture of non-ionic Dispersing Oily polymeric glycol Ester polietoxilado Facts with a Chain of Hydroxy Fatty Acid (Poly) with 12 - 20 carbons with a Weight of 0.5 to 8% with an HLB of 4 - 6 and a Copolymer of a-b-a of Fatty Acid a Chain of 12 - 20 car Bonds with a Weight of 0.5 - 5%, (c) a mixture of Fatty alcohol polietoxilado with a Weight of 0.5 - 15% polipropoxilado Fatty Alcohol and / or with a Weight of 1 - 25%, with an HLB of 12 - 16, d) at least one Derivative of sorbitan polietoxilado and / or polipropoxilado weighing 3 - 30% with an HLB of 12 - 16), and a Sodium Salt alquilbencenosulfonada or Calcium alkyl Chain, 10 - 14 Carbon ATOMS, with a Weight of 3 - 19%, f) a Salt cationic di -Tri - and tetravalent with a Weight of 0.001 to 3% g), An Oily Phase selected of paraffinic Oils, naphtha Aromatic Plant, synthetically modified vegetable oils, and mixtures thereof, with a Weight of 30% - 70%, H) optionally, cationic Surface Active Ingredients or anioni CA, nonionic, not mentioned in the claim 1 B, antioxidants, UV and sunlightAntimicrobial agents, pH regulators, viscosity Modifiers, Magnesium Aluminium silicate, Magnesium silicates, aluminosilicates, Clays, smectite, smectite Clays modified, modified, antifoaming agents, Dyes, Markers for Tracing Origin of the product.Claim 7: Oily dispersion according to claim 1, characterized in that it contains, on the percentage of total weight of the formulation of Oily dispersion: a) at least one selected neonicotinoid imidacloprid, Thiamethoxam, tiacloprida, penconazole, acetamiprida, Clot Dinetofurano ianidina, with a Weight of 5 to 35%(b) a mixture of non Ionic polymeric Dispersing Oily with a polietoxilado glycol Ester Chain Hydroxy Fatty Acid (Poly) with 12 - 20 carbons with a Weight of 0.5 to 8% with an HLB of 4 - 6 and a Copolymer of a-b-a fatty acid with a Chain of 12 - 20 carbons With a Weight of 0.5 - 3%, (c) a mixture made with 15 - 25 mol polietoxilado stearyl alcohol with a Weight of 0.5 - 10 - 25%, 25 oleilo polietoxilado moles of alcohol with a Weight of 0.5 - 10% and 10 to 20 mol monoestearilo polipropoxilado ether with a Weight of 1 - 15% with an HLB of 12 - 16, (d) a mix made of 15 - 25 moles of polyoxyethylene trioleate or with a Weight of 5 to 20% and 20 to 50 mol hepta 9-octadecenoate sorbitan polietoxilado with a Weight of 2 - 20%, with a HLB of 12 - 16, and calcium or Sodium dodecylbenzenesulphonate) with a Weight of 8 - 19%,(f) a paraffinic oil or vegetable with a Weight of 30% - 70%, g) Aluminium sulphate Monohydrate in anhydrous State, or any State hydrated with a Weight of 0.005 to 0.3%, a organomodificada smectite (i) with a Weight of 0.3% - 3%.Claim 1: An Oily dispersion according to claim 1 or to claim 7, characterized in that it also contains suspended microcapsules containing neonicotinoid Insecticides and / or other different neonicotinoids, or a Concentrated Emulsion, emulsion in AG UA, concentrated in suspension in waterSuspoemulsion containing neonicotinoid Insecticides and / or other various of neonicotinoids. Claim 1: the use of Oily dispersion of claim 1 or 7 or 14 to kill insects, mites, Fleas, ticks, spiders and / or Agrochemical Applications, Veterinary, for the home and garden or medicinal.