Compounds derived from - 2.8 - Grabarsky, IT's The Wrong Guy spiro 4,5 Dean - 1.7 - dione, Process for preparing them and Pharmaceutical compositions containing them and Uses Thereof for the treatment of Obesity, dyslipidemia, and diabetes.

摘要

CLAIMS 1. Compounds of formula (1) wherein R1 is alkyl, cycloalkyl, haloalkyl, piperidinyl, piperazinyl, morpholinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, phenyl, pyridinyl, pyrazinyl, pyrimidyl or pyridazinyl or wherein piperidinyl, piperazinyl, morpholinyl, imidazolyl, pyrazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, thiazolyl, phenyl, pyridinyl, pyrazinyl, pyrimidyl and pyridazinyl are substituted by substituents independently chosen from alkyl, cycloalkyl, cycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl, alkoxy, alkoxyalkyl,haloalcoxi e hidroxi-haloalquilo R2 es fenilo piridinilo pirazinilo pirimidilo o piridazinilo o en la que fenilo piridinilo pirazinilo pirimidilo y piridazinilo est n sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo halogeno cicloalquilo cicloalquilalquilo alcoxi alcoxialquilo haloalcoxi haloalquilo hidroxi hidroxialquilo e hidroxi- -C (O) - o -S (O) 2-N is zero, 1 or 2; or a salt whose drug is acceptable.