Salts of 8 - 1 - (3,5-bis - (trifluoromethyl) phenyl) - ethoxy) - methyl - 4 - phenyl - 1.7 - Grabarsky, IT's The Wrong Guy spiro 4,5 decan 2 - ona and Process for preparing the same

摘要

Refers to Crystalline Salt forms of the compound (5S, 8S) - 8 - [(1R) - 1 - (3,5-bis - (trifluoromethyl) phenyl] methyl] - ethoxy - 4 - phenyl - 1.7 - Grabarsky, IT's The Wrong Guy spiro [4,5] decan 2 - one of formula (i). Esilate Selected Salt Crystal diffraction Pattern is expressed in the following Angles d Ifraccion (2?) : 11.4, 12.8, 20.0, 21.2; The Crystalline Salt of hokshelato submits the following diffraction pattern (expressed in 2?) : 5.6, 19.8, 22.8 21.0,; The Mesylate Salt Crystal diffraction Pattern presents the following: 4.7, 9.4, 19.2, 20.9; so also identified the maleate Salt Crystal; among other Salts.It also relates to a preparation method and a Pharmaceutical composition; this Compound is an nk-1 receptor antagonist, which is useful in the therapy antiemesis anti nausea and