Methods and Reagents for effective and targeted gene transfer to monocytes and macrophages

摘要

Useful and biosecure vector to transfer genetic material to CD14 + mononuclear Cells (monocytes and monocyte derived macrophages) in an effective way and specific. The Implementation makes use of the Chimeric Human adenovirus 5 vector carrying Short Fibre ad40 enterotropico to transfer genetic material to target CD14 + mononuclear cells.Claim 3: in vitro procedure to provide a compound of interest in a monocyte macrophage Cell Lineage comprising contacting Said cell with a nanocarrier that carries the compound of interest and the carrier contains at least one part d Short Fibre and Protein of adenovirus Group f or a functionally equivalent variantSame. Claim 1: nanocarrier that includes a product of interest and at least a part of the Short Fiber Protein of adenovirus Subgroup f or a functionally equivalent Variant thereof for use in the treatment of a disease Associated Cell Lineage monoci Cough - macrophages.