High Concentration Antibody formulations, method for reducing the viscosity of a Protein formulation, method of use

摘要

Claim 1: a sterile Liquid formulation which has an absolute viscosity of approximately COP 10 or less comprises (a) a antiesclerostina immunoglobulin a concentration of at least 70 mg / ml; and (b) Calcium acetate at a concentration that is located in the interval d And about 1 mm to 20 mm.Claim 4: a sterile Liquid formulation which has an absolute viscosity of approximately COP 10 or less comprises (a) a antiesclerostina immune globulin at a concentration of approximately 70 mg / ml to approximately 200 mg / ml; and (b) an acetate Salt and / or buffer Acetate at a concentration that is in the range of about 10 mm to approx.And 50 mm acetate, which comprises the immunoglobulin sequences of amino acids: SEC. With no. of ident: 14 and / or sec. With no. of ident: 12; or sec. With no. of ident: 86 and / or sec. With no. of ident: 84; or sec. With no. of ident: 68 and / or sec. With no. of ident: 66; or sec. With no. of ident: 154 and / or sec. With no. of ident: 152; or sec. With no. of ident: 182 and / or sec. With no ident.- 180 sec. With no. of ident: 208 and / or sec. With no. of ident: 207; or sec. With no. of ident: 216 and / or sec. With no. of ident: 214; or sec. With no. of ident: 238 and / or sec. With no. of ident: 236.Claim 8: the formulation of any of claims 1 to 7, where the formulation also includes a polyol such as sucrose, for example, in an amount in the range of about 4% to about 6% w / v P / V.Claim 12: a sterile Liquid formulation which has an absolute viscosity of approximately COP 10 or less comprising: (a) AB 5 at a concentration of at least 70 mg / ml to approximately 200 mg / ml; (b) Calcium acetate at a concentration that is in the range of Approximately 1 mm to 20 mm; and (e) a polyol such as sucrose, e.g.In an amount in the range of about 4% to about 6% w / v P / V.Claim 14: a method of using a therapeutically effective amount of the formulation of any of claims 1 to 9, 12 and 13 for treating a patient suffering from Orthopedic procedures, procedures for Dental implant surgery, Joint Replacement, injert Cosmetic Surgery or Bone, bone and Bone Repair, as Healing of Fractures,Lack of Union Healing, Healing of delayed Unions and facial Reconstruction.