use of cxcr4 chemokine receptor binding compounds and methods to increase blood flow and promote tissue regeneration

摘要

USE OF COMPOUNDS THAT CONNECT TO THE CXCR4 CHEMOCCIN RECEPTOR AND METHODS TO INCREASE BLOOD FLOW AND PROMOTE TISSUE REGENERATION. The present invention relates to methods for increasing blood flow and / or regenerating tissue using compounds that bind to the chemokine receptor CXCR4. Preferred embodiments of such compounds are of the formula Z-linker-Z '(1) in which Z is a cyclic polyamine containing 9-32 ring members of which 2-8 are nitrogen atoms, with such nitrogen atoms being separated each other by at least two carbon atoms, and in which such a heterocycle may optionally contain additional heteroatoms, in addition to nitrogen and / or may be fused to an additional ring system; or Z is of formula B wherein A comprises a monocyclic or bicyclic fused ring system containing at least one N and B is H or an organic half of 1-20 atoms; Z 'can be incorporated in a form as defined by Z above or, alternatively, it can be of the formula -N (R) - (CR2) nX where each R is independently H or direct, branched or cyclic (1-6C) alkyl , n is 1 or 2, and X is an aromatic ring, including heteroaromatic rings, or is a mercaptan; or Z ^ 1 ^ is of the formula -Ar (Y); where Ar is an aromatic or heteroaromatic moiety and each y is independently a non-interfering substituent and j is 0 to 3; "linker represents a bond, alkylene (1-6C), or it may comprise aryl, fused aryl, oxygen atoms contained in the alkylene chain, or it may contain keto groups or nitrogen or sulfur atoms.