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INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAINBARRIER PENETRATION AND METHOD FOR EXPOSINGINSECT BRAIN TO NANOPARTICLES
INSECT-BASED EX VIVO MODEL FOR TESTING BLOOD-BRAINBARRIER PENETRATION AND METHOD FOR EXPOSINGINSECT BRAIN TO NANOPARTICLES
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机译:基于昆虫的活血屏障渗透测试模型及将昆虫暴露于纳米粒子的方法
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摘要
There is provided an ex-vivo insect screening model to accurately determine blood-brain barrier penetration of different nanoparticles in order to improve the compound screening procedures/processes in the early drug discovery process. This object offers many advantages relative to prior technologies since insect models are more reliable tools for the decision-making process than the existing in vitro models, and will speed up the drug screening process and reduce the late phase attrition rate. Moreover, it will reduce the number of mammals sacrificed during the drug discovery phase.
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