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Transdermal patch with buprenorphine for use in the treatment of pain for a dosing interval of at least 4 days
Transdermal patch with buprenorphine for use in the treatment of pain for a dosing interval of at least 4 days
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机译:丁丙诺啡透皮贴剂用于治疗疼痛,给药间隔至少4天
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摘要
A sustained release formulation of buprenorphine is new. The composition comprises a transdermal delivery device which provides a first order release of buprenorphine over a 3-day dosing interval so that a maximum plasma concentration of 20 10 1052 pg/ml is obtained. the device then provides zero order kinetics over at least 2 more days.
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