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Toll-Like-Receptor-4 dysfunction and its biological applications
Toll-Like-Receptor-4 dysfunction and its biological applications
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机译:Toll样受体4功能障碍及其生物学应用
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摘要
The present invention relates to an in vitro method of assessing the sensitivity of a subject to a treatment of cancer, which method comprises detecting the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from the subject, the presence of said mutated TLR4 nucleic acid or abnormal TLR4 expression or activity being indicative of a resistance to said treatment. The detection of the presence of a mutated Toll Like Receptor 4 (TLR4) nucleic acid or an abnormal TLR4 protein expression or activity in a sample from a subject is also indicative of a predisposition to a cancer in the subject.
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