Radiochemical Purity not unsealed Colloidal compositions and Methods for the treatment of abnormal tissue

摘要

Some embodiments of the present description relates to compositions and Methods for the treatment of abnormal tissue (e.g., cancer). For example, a method May comprise administering to a subject in the region of abnormal Tissue composition (e.g., a Pharmaceutical Composition and / or radiopharmaceutical composition) that has a basic pH (e.g., increased approximately 9).In some embodiments, the radiopharmaceutical composition May comprise a mixture of (a) a First composition comprising a radionucleida Holmium - 166 free (166ho), non Radioactive, Colloidal, unsealed and / or Metallic ion of Holmium - 166 free (non Radioactive 166ho), Colloidal, unsealed (For example,166ho 3 +) and (b) a Second composition comprising LUTETIUM radionucleida - 177 free (non Radioactive 177lu), Colloidal, unsealed and / or LUTETIUM Metal Ion - 177 (177lu) Radioactive, non Colloidal, unsealed (For example, 177 LU3 +). A Radio Pharmaceutical composition in some Embodiments may include a Metal Ion and / or metal free, non Radioactive, Colloidal, unsealed (e.g.(126sb, antimony, antimony) - 126 - 127 - 132 (127sb), caesium (132cs), EUROPIUM (136eu - 136 - 159), gadolinium LUTETIUM (159gd) - 177 (32 177lu), Phosphorus (32P), PROMETHIUM (148pm - 148 - 149), PROMETHIUM (149pm) - 86 (86rb Rubidium Strontium - 89), Tin (89Sr), 125 (125sn), YTTERBIUM (175yb - 175), and / or ions. Os).