COMPOSITIONS AND METHODS OF ELIMINATION OF GRAMORABLE BACTERIA

摘要

Disclosed are oral compositions for drug delivery with the specific administration of antibacterial agents in the ileum, cecum and / or colon, without substantial administration elsewhere in the gastrointestinal tract. The compositions include, as active agents, a combination of a macrolide or aminoglycoside or quinolone antibacterial agent and an anti-gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterial agents effective against gram-negative bacteria. The compositions can be used to treat infections or unwanted colonization in the colon and to provide effective decontamination of the colon flora from unwanted or potentially pathogenic bacteria.