N- (GETERO) ARYLPYRROLIDINE DERIVATIVES PYRAZOL-4-ILPYRROLO 2,3-d PYRIMIDINES AND PYRROL-3-ILPYRROLO 2,3-d PYRIMIDINES AS AN INITIATORS YANUS-I-I-I-I-I-I-I-I-I-I-I-IU-ZY-3-d)

摘要

The present invention relates to an N- (hetero) arylpyrrolidine derivative of the formula I which are JAK inhibitors, such as selective JAK1 inhibitors, used to treat diseases associated with Janus kinase activity, including, for example, inflammatory and autoimmune disorders, as well as cancer.