GRAFTED MACROMOLECULAR CONJUGATES OF DOXORUBICIN WITH ANTICANCER ACTIVITY AND METHOD OF THEIR PREPARATION

摘要

A polymeric drug, in which a cancerostatic connected via spacers containing hydrolytically cleavable hydrazone bonds is bound to a water-soluble polymeric carrier prepared on the basis of a N-(2-hydroxypropyl)methacrylamide copolymer, wherein the structure of the polymeric drug consists of the main chain of N-(2-hydroxypropyl)methacrylamide carrying the cancerostatic and another chain of N-(2-hydroxypropyl)methacrylamide - a graft, the molecular weights of the main chain and the grafts are selected so that both the main chain before bonding of the grafts and the grafts themselves are excludable from the body after degradation, while the total molecular weight of the grafted polymer exceeds the exclusion limit of the body, where said polymeric drug has a structure selected from 1a, 1b, 1c, 1d, 2, 3a, 3b, 4a, 4b, 4c and 5 structures disclosed in the description and a method of preparation thereof.