Arilmetoxi isoindolina derivatives and compositions containing Same, and Methods for using the same

摘要

The invention refers to formula compound: R is hydrogen or lower hydrocarbon, R1 is - (CH2) n - (o) or - isocyclododecane O-C (o) - isocyclododecane, in which isocyclododecane is replaced by lower hydrocarbon, hydrogen Xi, halogen or - (CH2) p-arilo, n is 0, 1 or 2, or 0 or 1, P is 0, 1 or 2, R2 CF3, Cyclopentyl cyclohexane can be replaced by hypoxia or halogen, indan-2-ilo, isopropyl isopropyl, isopropyl, arilo or isopropyl, in which the aromatic ring can be replaced by one or two substitutes selected from low tar, halogen, isopropyl, hydroxyl, CF3,OCF3 OCH2CF3 OCH2-cicloalquilo OCH2C (CH2OH) (CH2Cl) (CH3)S-lower alkyl, lower alkoxy, CH2-lower alkoxy, lower alkynyl or cyano, or with -C (O) -phenyl, -O-phenyl, -O-CH2-phenyl, phenyl or -CH2-phenyl, and in the that phenyl rings can optionally be substituted with halogen, -C (O) -lower alkyl, -C (O) -OH or -C (O) -O-lower alkyl, or aromatic rings are optionally substituted with heterocycloalkyl, OCH2- oxetane-3-yl or O-tetrahydropyran-4-yl, optionally substituted with lower alkyl, X is a bond, -NR'-,-CH2NH...-'CHR''- (CHR '') q-O-,-O- (CHR) q- o - (CH2) 2-It is an o-ch2-r bond, hydrogen or low tar. R '' is hydrogen, low tar, CF3, low oxygen, q is 0, 1, 2 or 3, or an acid salt acceptable for drugs. It has been found that the formula one compounds have good affinity with the receptors containing trace amines (taars),Especially Teri These compounds can be used to treat depression, anxiety, bipolar disorder, ADHD caused by lack of attention,Stress related diseases, psychosis, such as schizophrenia, Parkinson's disease and other neuropathy, such as Alzheimer's disease and other neurodegenerative diseases, epilepsy, migraine, hypertension, drug abuse and metabolic diseases Eating disorders, diabetes, diabetic complications, obesity, degreasing, energy consumption and absorption disorders, body temperature homeopathy and dysfunction, sleep and cirrhosis disorders, and cardiovascular diseases.