CRYSTALLINE ANHYDROUS MALEATE SALT OF 5-(Z)-(5-FLUORO-2-OXO 1,2-DIHYDRO-3H-INDOL-3-YLIDENE) METHYL-N-(2S)-2-HYDROXY-3-MORPHOLIN-4-YLPROPYL-2,4-DIMETHYL-1H-PYRROLE-3-CARBOXAMIDE

摘要

The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide, such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N-[(2S)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide salts, and methods of treating disorders such as cancer using such compositions.