ORAL PHARMACEUTICAL FORM FOR A SINGLE DAILY INTAKE COMBINING A METFORMIN AND AT LEAST ONE OTHER ANTIDIABETIC ACTIVE PRINCIPLE

摘要

The invention concerns oral galenic forms (tablets, capsules, powders and the like) wherein are associated a biguanide, preferably metformin and at least another anti-hyperglycemic active principle B. The invention aims at providing an antidiabetic (type II diabetes) oral pharmaceutical form containing: an active principle A consisting of metformin and at least another active principle B, capable of being easily swallowed, in a single daily dose. This is achieved by the inventive oral pharmaceutical form associating metformin and at least another antidiabetic active principle B (glibenclamide, pioglitazone hydrochloride, rosiglitazone maleate, nateglinide, glipizide, glimepiride). The invention is characterised in that it comprises capsules consisting each of a core based on metformin and by a coating film applied on the core and enabling prolonged release in vivo of metformin; and optionally capsules based on coated B and enabling prolonged release of B; the capsules based on metformin and the optional capsules based on B are designed such that the delivery rate of said galenic form is a single daily dose.