SINGLE-DAILY-DOSE ANTIDIABETIC ORAL PHARMACEUTICAL FORM COMPRISING A BIGUANIDE AND AT LEAST ANOTHER ACTIVE ACTIVE PRINCIPLE

摘要

An antidiabetic (type II diabetes) oral pharmaceutical form containing an active principle A which is a biguanide such as metformin and at least another active principle B, capable of being easily swallowed, in a single daily dose. The antidiabetic active principle B may be glibenclamide, pioglitazone hydrochloride, rosiglitazone maleate, nateglinide, glipizide or glimepiride. A capsule having a core based on metformin and a coating film applied on the core which enables prolonged release in vivo of metformin is disclosed. The capsule may optionally be used with capsules based on coated active principle B, the coating enabling prolonged release of B. The capsules are designed such that the delivery rate of the galenic form is a single daily dose.