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COMBINATION OF AN NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONIN REUPTAKE INHIBITOR FOR THE TREATMENT OF DEPRESSION AND OTHER MOOD DISORDERS
COMBINATION OF AN NMDA RECEPTOR ANTAGONIST AND A SELECTIVE SEROTONIN REUPTAKE INHIBITOR FOR THE TREATMENT OF DEPRESSION AND OTHER MOOD DISORDERS
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机译:NMDA受体拮抗剂与选择性5-羟色胺再摄取抑制剂的组合,用于治疗抑郁症和其他情绪障碍
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摘要
The present invention provides a method for the treatment of depression, including treatment-resistant depression, and other mood disorders using a combination of an NMDA receptor antagonist and a SSRI, a NARI, a dual SSRI/NARI (a SNRI), or a tricyclic antidepressant (TCA). It has unexpectedly been shown that the combination has a synergistic and potentiated effect of either compound as monotherapy, resulting in an enhanced therapeutic effect at lower doses.
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