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GENETICALLY ENGINEERED BLEB PREPARATION ISOLATED FROM A MODIFIED NEISSERIA, MORAXELLA OR HAEMOPHILUS STRAIN AND ITS USE IN THE PREPARATION OF A VACCINE
GENETICALLY ENGINEERED BLEB PREPARATION ISOLATED FROM A MODIFIED NEISSERIA, MORAXELLA OR HAEMOPHILUS STRAIN AND ITS USE IN THE PREPARATION OF A VACCINE
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机译:改良的奈瑟氏菌,莫拉菌或嗜血杆菌菌株的基因工程化BLEB制备及其在疫苗制备中的用途
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摘要
The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
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