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USE OF OLIGONUCLEOTIDES WITH MODIFIED BASES AS ANTIVIRAL AGENTS
USE OF OLIGONUCLEOTIDES WITH MODIFIED BASES AS ANTIVIRAL AGENTS
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机译:修饰碱基的寡核苷酸作为抗病毒剂的使用
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摘要
The present invention relates to the use of oligonucleotides having modified nucleobases to inhibit gene expression and/or replication of viruses in a subject. The modified nucleobases may be mercapto-modified bases or hydroxy-modified nucleobases. It is contemplated that the oligonucleotides further comprise a nuclease complex which enhances anti-viral activity of the oligonucleotides.
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