A MICROBIAL TRANSFORMATION PROCESS FOR SYNTHESIS OF FENOFIBRIC ACID FROM FENOFIBRATE

摘要

Disclosed is a microbial transformation process for synthesis of fenofibric acid from fenofibrate using a mesophilic fungus Cunninghamella blakesleeana NCIM 687. The disclosed process comprises growing the fungal culture in a nutrient medium under controlled conditions and pH. Further in the process feeding of fenofibrate to the culture of mesophilic fungus C. blakesleeana is done separately at 27 °C and incubated for 4 days on rotator shaker (120 rpm) which yielded fenofibric acid. The culture broth was extracted using ethyl acetate yielding fenofibric acid (II). Other advantage of the disclosed process is that it is not only ecofriendly but also simplifies the process in an economical way. The fenofibric acid obtained by this process is the active metabolite which is more potent than fenofibrate in treatment of Hyperlipidemia and Hypertriglycerdemia.