The present invention relates to improved process for hydrolysis of N-[(2’-(1H-Tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-(L)-valine ester derivative of formula (II), henceforth referred as “Valsartan ester derivative” , which is penultimate intermediate for the preparation of Valsartan of formula (I), chemically known as (S)-N-(1-Carboxy-2-methyl-prop-1-yl)-N-[2’(1H-tetrozol-5-yl)biphenyl-4-ylmethyl]-amine, Wherein R1 represents C1-C6 alkyl selected from methyl, ethyl, n-propyl, iso-propyl, n-butyl, tert-butyl or 2-methyl-propyl; substituted or unsubstituted phenyl group or like and P is hydrogen or a tetrazole protecting group.
展开▼
