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PROCESS FOR PREPARING (11BETA, 16ALPHA)-9-FLUORO-11-HYDROXY-16,17 -1-METHYL-ETHYLIDENEBIS(OXY)-21-1-OXO-4-(NITROOXYMETHYL)BENZ OXYPREGNA-1,4-DIEN-3,20-DIONE.
PROCESS FOR PREPARING (11BETA, 16ALPHA)-9-FLUORO-11-HYDROXY-16,17 -1-METHYL-ETHYLIDENEBIS(OXY)-21-1-OXO-4-(NITROOXYMETHYL)BENZ OXYPREGNA-1,4-DIEN-3,20-DIONE.
This invention relates to a new process for preparing (11 β, 16α)-9-fluoro-11 - hydroxy-16,17-[1 -methyl -ethyl idenebis(oxy)]-21 -[1 -oxo-[4- (nitrooxymethyl)benzoxy]]pregna-1,4-dien-3,20-dione, comprising the steps of (i) reaction of triamcinolone acetonide with 4-(nitrooxymethyl)benzoic, 4- dimethylaminopyridine and N-N'-diisopropylcarbodiimide, (ii) crystallisation, and (iii) controlled precipitation.
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