HUMAN MONOCLONAL ANTIBODIES DERIVED FROM HUMAN B CELLS AND HAVING NEUTRALIZING ACTIVITY AGAINST INFLUENZA A VIRUSES.

摘要

The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with influenza A viruses, wherein the monoclonal antibodies have neutralizing activity against influenza A viruses. The anti-influenza A virus monoclonal antibody of the present invention has binding and neutralizing activities against at least one influenza A virus selected from the group consisting of influenza A virus H1, H2 and H5 subtypes, and thus it is useful for the prevention and treatment of a disease caused by the influenza A virus and is also useful for diagnosis of influenza A virus infection. The present invention relates to human monoclonal antibodies derived from human B cells present in the blood of patients who had recovered from infection with influenza A viruses, wherein the monoclonal antibodies have neutralizing activity against influenza A viruses. The anti-influenza A virus monoclonal antibody of the present invention has binding and neutralizing activities against at least one influenza A virus selected from the group consisting of influenza A virus H1, H2 and H5 subtypes, and thus it is useful for the prevention and treatment of a disease caused by the influenza A virus and is also useful for diagnosis of influenza A virus infection. According to one embodiment of the present invention, disclosed is a method for determining an antenna in a terminal which includes a plurality of non-directional antennas. The antenna determination method may comprise the steps of: performing a measurement on a reference signal from one or more cells through the plurality of non-directional antennas at an initial state; selecting a cell on the basis of a measured value; selecting an antenna to be used for transmission and reception among the plurality of non-directional antennas on the basis of the measured value; monitoring whether or not a long-term timer has elapsed; and again performing the measurement step, the cell selection step, and the antenna selection step when the long-term timer has elapsed.