GENE CLUSTER ENCODING A NYSTATIN POLYKETIDE SYNTHASE AND ITS MANIPULATION AND UTILITY

摘要

The invention provides a nucleic acid molecule comprising: a nucleotide sequence as shown in SEQ ID No. 35; wherein said sequence preferably encodes or is complementary to a sequence encoding a nystatin PKS enzyme or a part thereof. Also provided are part of such molecules and polypeptides (and parts thereof) encoded by such a nucleic acid molecule, and the use of such molecules and polypeptides in facilitating nystatin biosynthesis and in the synthesis of nystatin derivatives and novel polyketide as macrolide structures.