Renin inhibitors such as aliskiren for the treatment of rebound hypertension

摘要

Disclosed is the use of 2(S),4( S),5(S),7 (S)-N-(3-amino-2,2-dimethyl-3-oxopropyl)-2,7-di(1-methylethyl)-4-hydroxy-5-amino-8-[4-methoxy-3-(3-methoxy-propoxy)phenyl]-octanamide, also known as Aliskiren, for treating hypertension, wherein the medicament is adapted for administration according to a once daily administration therapy with intermittent discontinuation for a time period of from 1 day to four weeks, the antihypertensive effect being sustained after said intermittent discontinuation of the medicament.