IN VIVO TRANSFORMATION OF PANCREATIC ACINAR CELLS INTO INSULIN-PRODUCING CELLS

摘要

Disclosed is a single construct vector for expressing betacellulin (BTC) and Pancreas Duodenum Homeobox-1 (PDX1) in the manufacture of a medicament for inducing insulin production to treat diabetes. Also disclosed is a composition comprising a microbubble capable of being destroyed upon exposure to ultrasound; and a nucleic acid expression construct that expresses betacellulin, and PDX1 when transfected into acinar cells disposed within the microbubble.