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Method for peforming an immunodiffusion assay (SRID) for influenza hemagglutinin antigen based on desorbing the antigen from the aluminium adjuvant salt
Method for peforming an immunodiffusion assay (SRID) for influenza hemagglutinin antigen based on desorbing the antigen from the aluminium adjuvant salt
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机译:从铝佐剂盐中解吸抗原进行流感血凝素抗原的免疫扩散测定(SRID)的方法
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摘要
Discloses a method for performing an immunodiffusion assay, comprising: (a) obtaining a starting composition comprising an influenza virus hemagglutinin (HA) antigen, wherein the HA antigen is adsorbed to an adjuvant that comprises an aluminium sa (b) treating the starting composition with a mixture comprising a salt at a concentration range from 10mM to 1000mM and a surfactant at a concentration range from 0.1% to 15% (w/v) to desorb the HA antigen from the adjuvant; and (c) allowing the desorbed composition, comprising the desorbed HA antigen, to diffuse into a gel comprising an antibody specific to the antigen. The method finds application in determining an accurate level of influenza virus HA antigens in compositions containing aluminium salts, which had previously caused immunodiffusion assays to give inaccurate results.
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