首页> 外国专利> New polymorphic forms of dihydrogen phosphate - 6 - (1 - methyl - 1h-pyrazol-4-yl) - 2 - (3 - 5 - (2 - (4 - il - ethoxy) - pyrimidin-2-yl) - Benzyl - il - 2} - 2H - pyridazin-3 3-one and processes for its preparation

New polymorphic forms of dihydrogen phosphate - 6 - (1 - methyl - 1h-pyrazol-4-yl) - 2 - (3 - 5 - (2 - (4 - il - ethoxy) - pyrimidin-2-yl) - Benzyl - il - 2} - 2H - pyridazin-3 3-one and processes for its preparation

机译:磷酸二氢的新多晶型物-6-(1--甲基-1h-吡唑-4-基)-2-(3-[5-(2-(4-il-乙氧基)-嘧啶-2-基)-苄基-il-2}-2H-哒嗪-3 3-酮及其制备方法

摘要

Referring to the dihydrogen phosphate - 6 - (1 - methyl - 1h-pyrazol-4-yl) - 2 - (3 - [5 - (2 - (4 - il - extoxi - pyrimidin-2-yl) - yl] - Benzyl - 2} - 2H - pyridazin-3 3-one, their forms and solvates clear as Crystal form A1 characterized by XRD Peaks 18,4u00ba, 18,8u00ba, 23,7u00ba, 24,2u00ba, 26,4u00ba and 28,2u00ba 2 Theta ( u00b10,1u00ba 2theta) emepleando cu Radiation kalfa1 or Crystalline form H1 with Peaks of XRD 3,1u00ba, 94th and 18,8u00ba 2 Theta (u00b10,1u00ba 2theta). Farmaceutca also relates to a Composition and a process of Preparation. These compounds are useful in the treatment of diseases mediated by Kinases
机译:涉及磷酸二氢-6-(1--甲基-1h-吡唑-4-基)-2-(3-[5-(2-(4-il-外毒素-嘧啶-2-基)-yl]-苄基-2}-2H-哒嗪-3 3-酮,其形式和溶剂化物透明,为晶体形式A1,特征在于XRD峰18,4 u00ba,18,8 u00ba,23,7 u00ba,24,2 u00ba ,26,4 u00ba和28,2 u00ba 2 Theta( u00b10,1 u00ba 2theta)emepleando cu辐射kalfa1或晶体形式H1,其XRD峰分别为3,1 u00ba,94和18,8 u00ba 2 Theta ( u00b10,1 u00ba 2theta)。Farmaceutca还涉及一种组合物及其制备方法,这些化合物可用于治疗激酶介导的疾病

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